Bin Wang 2018-01-18T14:49:14+00:00

Bin Wang

Tempe, Arizona
Phone:  (480) 830-2700
Fax:  (480) 830-2717

Contact Me

Areas of Practice:

Bin Wang’s practice focuses on patent prosecution in the areas of Biotechnology, Pharmaceuticals, and Life Sciences:

  • transgenic animals, stem cells, steroid hormone, modulator of cytokine, kinase inhibitor, small molecule therapeutics, anti-aging agent, fungal etiologic agents, cell-free DNA, splice variants, and RNAi silencing molecules;
  • methods of whole genome sequencing, small RNA purification, heteroresistant pathogen detection, bacterium subtyping, biomarker creation, breath test, and biological waste water treatment; and
  • device and methods of diagnosing, classifying, and treating diseases and conditions such as Alzheimer’s, motor neuron diseases, neuronal cell damage, cancer, lupus, bone marrow failure, infection, uterine contractility disorder, and liver disease

Prior to attending law school, Bin was a scientist. Bin’s technical expertise spans genetics, molecular biology, protein chemistry, biophysics, electrophysiology, pharmacology, and neuroscience.

Education:

  • J.D., Cum Laude, Baylor University Law School
    • Baylor Law Review
    • Dean’s Academic Excellence Full Scholarship
    • Jim Barlow Memorial Award
    • Loy M. Simpkins Memorial Award
    • State Bar of TX Oil, Gas & Energy Law Resources Section Scholarships
    • Thomas M. Featherston, Jr. Estate Planning Award
  • Ph.D., Molecular Biology, University of Texas at Austin
  • B.S., Genetics, Fudan University 

Past Professional Experience:

  • The Eastern District of Texas, United States District Court (Tyler): Extern to the Honorable K. Nicole Mitchell
  • Burns Anderson Jury & Brenner, LLP: Law Clerk
  • The University of Texas Health Science Center at San Antonio: Research Assistant Professor
    • Co-Investigator, National Institute of Health (NIH)
    • Principal-Investigator, American Heart Association
  • The University of Texas Health Science Center at San Antonio: Postdoctoral Fellow
    • NIH Individual National Research Service Award
    • NIH Institutional National Research Service Award
    • Postdoctoral Program Coordinator, Department of Physiology
  • Stanford Medical School: Postdoctoral Fellow
    • Dean’s Postdoctoral Fellowship 

Peer Reviewed Journal Papers:

  • Molecular Biology, Mouse Knockout Models, Development, and Immunology
    • Wang B (co-first author), Weidenfeld J, Lu MM, Maika S, Kuziel WA, Morrisey EE, Tucker PW. (2004). Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation. Development 131:4477-87.
    • Hui H, Wang B, Borde M, Maika S, Allred L, Tucker PW and Rao A. (2006). Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol. 7:819-26. Recommended by Faculty 1000 Immunology. Commented in Nat Immunol.: FOXtrot and RAGtime in B cells.
    • Dasen JS, De Camilli A, Wang B, Tucker PW, and Jessell TM. (2008). The entire Hox repertoire for motor neuron diversity and connectivity is gated by a single accessory factor, FoxP1. Cell 134(2):304-316. Commented in HHMI news: Researchers Discover Key Gene for Making Motor Neurons.
  • Ion Channel Biophysics and Physiology
    • Luik RM, Wang B (co-first author), Prakriya M, Wu MM, and Lewis RS. (2008). Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation. Nature 454: 538-42. Recommended by Faculty 1000 Cell Biology and Faculty 1000 Immunology.
    • Wang B, Rothberg BS, Brenner R. (2006). Mechanism of beta4 subunit modulation of BK channels. J Gen Physiol. 127:449-65.
    • Wang B and Brenner R. (2006). An S6 mutation in BK channels reveals beta1 subunit effects on intrinsic and voltage-dependent gating. J Gen Physiol. 128:731-44.
    • Wang B, Rothberg BS, Brenner R. (2009). Mechanism of increased BK channel activation from a channel mutation that causes epilepsy. J Gen Physiol. 133:283-94.
    • Gruslova A, Semenov I and Wang B (corresponding author). (2012). An extracellular domain of the accessory beta1 subunit modulates the voltage sensor and gate of BK channels. J Gen Physiol. 139:57-67.
    • Nguyen NV, Gruslova A, Kosiba WA and Wang B (corresponding author). (2013). Combined single and macroscopic recording techniques to analyze gating mechanisms of the large conductance Ca2+ and voltage activated (BK) potassium channel. Methods Mol Biol. 998:133-47.
  • Pharmacology
    • Semenov I, Wang B, Herlihy JT and Brenner R. (2006). BK channel beta1-subunit regulation of calcium handling and constriction in tracheal smooth muscle. Am J Physiol Lung Cell Mol Physiol. 291:L802-10.
    • Semenov I, Wang B, Herlihy JT and Brenner R. (2011). BK channel beta1 subunits regulate airway contraction secondary to M2 muscarinic acetylcholine receptor mediated depolarization. J Physiol. 589:1803-17.
    • Zhang D, Wang X, Wang B, Garza JC, Fang X, Wang J, Scherer PE, Brenner R, Zhang W, Lu XY. (2017). Adiponectin regulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors. Mol. Psychiatry 22(7):1044-1055.
  • Genetics and Biochemistry
    • Seibold, MA, Wang B (co-first author), Eng C, Kumar G, Beckman K, Choudhry S, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Burchard EG and Brenner R. (2008). An African-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severity. Hum Mol Genet. 17: 2681-90.
    • Wang B, Lin D, Li C, Tucker P. (2003). Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors. J Biol Chem. 278:24259-68.
    • Thomas T, Wang B, Brenner R, Atkinson NS. (1997). Novel embryonic regulation of Ca2+-activated K+ channel expression in Drosophila. Invert Neurosci. 2:283-91.
    • Bohm RA, Wang B, Brenner R, Atkinson NS. (2000). Transcriptional control of Ca2+-activated K+ channel expression: identification of a second, evolutionarily conserved, neuronal promoter. Exp Biol. 203 Pt 4:693-704.
  • Neuroscience
    • Wang B, Bugay V, Ling L, Chuang HH, Jaffe DB, Brenner R. (2016). Knockout of the BK β4 subunit promotes a functional coupling of BK channels and ryanodine receptors that mediate a fAHP-induced increase in excitability. J Neurophysiol. 116(2):456-65.
    • Jaffe DB, Wang B and Brenner R. (2011). Shaping of action potentials by type I and type II BK channels. Neuroscience. 192:205-18.
    • Petrik D, Wang B and Brenner R. (2011). Modulation by the BK accessory β4 subunit of phosphorylation-dependent changes in excitability of dentate gyrus granule neurons. Eur J Neurosci. 34:695-704.
    • Boiko N, Kucher V, Wang B and Stockand JD. (2014). Restrictive expression of acid-sensing ion channel 5 (asic5) in unipolar brush cells of the vestibulocerebellum. PLoS One. 9(3):e91326.
    • Wang B, Jaffe DB, Brenner R. (2014) Current understanding of iberiotoxin-resistant BK channels in the nervous system. Front Physiol. 5:382.

Book Chapters

  • Wang B, Chen, QH, Brenner R. Proepileptic effects of BK channel gene mutations. Encyclopedia of Basic Epilepsy Research. Elsevier Press; 2009.
  • Nguyen NV, Gruslova A, Kosiba WA and Wang B. Combined single and macroscopic recording techniques to analyze gating mechanisms of the large conductance Ca2+ and voltage activated (BK) potassium channel In: Nikita Gamper, Editor. Ion Channels. Methods and Protocols, 2nd edition. Humana Press; 2013.

Admitted to Practice:

  • United States Patent and Trademark Office
  • State of Texas

Languages:

  • Chinese
  • English